The university said it had concluded negotiations that have lasted about a year.
The school said 23 deals are fully signed and three are agreements in principle. The school faces six other claims, and the university says it believes some do not have merit while others may produce settlements.
The settlements have been unfolding since mid-August, when attorneys for the accusers began to disclose them.
Sandusky, 69, has been pursuing appeals while he serves a 30- to 60-year state prison sentence.
Three former administrators await trial in
Eight young men testified against Sandusky, describing a range of abuse they said went from grooming and manipulation to fondling, oral sex and anal rape when they were boys.
Sandusky did not testify at his trial but has long asserted his innocence. He has acknowledged he showered with boys but insisted he never molested them.
The abuse scandal rocked